GOTOKU CHEMICAL COMPANY LTD.

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Introduction:

carmellose calcium is a chemical modified cellulose containing a chelate structure of calcium that creates a water insoluble and hydration.

is effective in the disintegration and dissolution of drugs.

rapidly absorbs water needed for swelling and causes to a good short disintegration time.
Though

is still insoluble in water, yet it shows hydrophilic prorerty.Swelling property of

make it dispersible to primary particles from tablet state, which is very effective to promorte the solubility of drugs and thereby contribute to the bioavailability.

was listed in USP-XXI, US-NF XVI and EP and moreover was chosen International Harmonization Monographs.

offers the high utility values due to the following properties.

Assurrance of high quality.
Good water uptake and rapid swelling properties.
Function in both wet granulation and direct comporession.
Rapid disintegration time.
Good release and dissolution of drugs.
High compressibility
High long-term stability

The chemical structure formula of

is shown in the following figure.

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