| 1949 |
Shoichi Nakayama (Founder)
established Gotoku Chemical Promotion Partnership for the purpose
of the production and distribution of chemicals, food additives, and
the like. |
| 1950 |
Launched CMC-Na (Sodium
Cellulose Glycolate) by the name of T.P.T brand (Original proposer
of the trademark, Shoichi Nakayama) by the authority and approval
of the Agency of Industrial Science and Technology (of those days).
|
| 1952 |
CMC-Na (Official title
of the food additive : Carmellose Sodium ) was listed in the Japanese
Standards of Food Additives First edition and authorized and approved
as the food additive. Launched CMC-Na by the name of Food Additive
T.P.T. to go through the food industry in earnest. |
| 1961 |
As a leader, researched
and developed Disintegrant CMC-Ca (Official title of the food additive
: Carmellose Calcium) to accomplish commercialization. Placed it on
the market by the name of E.C.G-505 (Original proposer of the trademark,
Shoichi Nakayama), kicking off market cultivation as the sole distributor
to extend sales activities nationwide. |
| 1963 |
CMC-Ca (Carmellose Calcium)
was listed in the Japanese Standards of Food Additives Fourth edition.
Authorized and approved as the food additive, it was put on the market
by the name of Food Additive E.C.G-505.(Gotoku Chemical Promotion,
the sole distributor) |
| 1965 |
Obtained the patent license of Disintegrant CMC-Ca and started
exclusive selling nationwide as the sole distributor of CMC-Ca (E.C.G-505)
toward market expansion.
|
| 1966 |
CMC-Ca (Official title
by the Japanese Pharmacopoeia :Calcium Carboxymethylcellulose ) was
listed in the Japanese Pharmacopoeia Seventh edition Part‡U,being authorized
and approved as one of the JP drugs. |
|
1967
|
Originally researched
and developed Disintegrant CMC-H (Carmellose) to accomplish commercialization.
Placed it on the market by the name of NS-300 brand (Original proposer
of the trademark, Shoichi Nakayama), advancing market cultivation
as the sole distributor with the goal of nationwide sales. |
| 1982 |
Started selling Disintegrant
E.C.G-505 as the JP drug. (Gotoku Chemical Promotion, the sole distributor)
Won No.1 market share in the disintegrant sector along with the broad
expansion of the pharmaceutical industry market. |
| 1983 |
CMC-H (Official title by the Japanese
Standards for Pharmaceutical Ingredients:Carboxymethyl cellulose)
was listed in the Japanese Standards for Pharmaceutical Ingredients
(Abbreviated name : JSPI), being authorized and approved as the quasi
JP drug. |
| 1984 |
Launched Disintegrant NS-300(CMC-H) as the JSPI drug (authorized
and approved by the Japanese Standards for Pharmaceutical Ingredients).
(Gotoku Chemical Promotion, the sole distributor)
|
| 1985 |
Founder, Shoichi Nakayama
acceded to Representative Partner & Chairman. Yukihiro Nakayama
was designated as Representative Partner & President (experienced
in Accountants Manager, Business Manager and Vice President).
Disintegrant E.C.G-505 (CMC-Ca) was listed in USP/NF with international
appreciation.
*USP=United States Pharmacopoeia
*NF=National Formulary |
| 1986 |
CMC-H (Official title by
the Japanese Pharmacopoeia: Carboxymethylcellulose) was listed in
the Japanese Pharmacopoeia, authorized and approved as the JP drug.
|
| 1987 |
Started selling Disintegrant NS-300
(CMC-H) as the JP drug. (Gotoku Chemical Promotion, the sole distributor)
NS-300 gained a favorable position of the efficient disintegrant.
|
| 1989 |
On the occasion of the 40th anniversary
of the foundation, Partnership was reorganized into Company Limited.
Gotoku Chemical Co.,Ltd. newly started.
Yukihiro Nakayama acceded to Representative Director & President.
|
| 1991 |
Disintegrant E.C.G-505 (CMC-Ca) was
accepted as one of "the ICH Harmonisation Monographs", the
pharmaceutical excipients of the tripolar world: Japan, America and
Europe (25 items of most frequently used disintegrants in the world).
|
| 1992 |
Came into action as one of the founding
members of the Japan Pharmaceutical Excipients Council. Aiming at
International Harmonisation together with Domestic Harmonisation.
|
| 1993 |
Disintegrant E.C.G-505 (CMC-Ca), time-proven
in Europe, was listed in EP.
*EP=European Pharmacopoeia |
| 1996
|
Disintegrant NS-300 (CMC-H) was liste in "the Addendum of
ICH Harmonisation monographs."
|
